Genetic Variation, β-blockers, and Perioperative Myocardial Infarction

Due caution using early β-blockers for acute myocardial infarction

Outcomes: The two pre-specified co-primary outcomes were: (1) composite of death, reinfarction, or cardiac arrest; and (2) death from any cause during the scheduled treatment period. Comparisons were by intention to treat, and used the log-rank method. This study is registered with ClinicalTrials.gov, number NCT 00222573. Results: Neither of the co-primary outcomes was significantly reduced by ...

Should we use β‑blockers for myocardial infarction?

Perioperative myocardial infarction.

More than 230 million major surgeries are performed annually worldwide,1 and this number grows continuously. The 30-day mortality associated with moderateto high-risk noncardiac surgery in recent large cohorts and population-based studies exceeds 2%2– 4 and surpasses 5% in patients at high cardiac risk.5 Cardiac complications constitute the most common cause of postoperative morbidity and morta...

Beta-Blockers and Depression After Myocardial Infarction

OBJECTIVES The purpose of this research was to explore the prospective relationship between the use of beta-blockers and depression in myocardial infarction (MI) patients. BACKGROUND Beta-blocker use has been reported to be associated with the development of depression, but the methodological quality of studies in this field is weak. METHODS In a multicenter study, MI patients (n 127 non–beta-b...

Triggers of perioperative myocardial ischaemia and infarction.

Cardiac complications are a major cause of morbidity and mortality after non-cardiac surgery. 64 However, the exact nature of perioperative myocardial injury remains elusive and an area of continued debate and controversy. 64 If triggers of perioperative myocardial ischaemic events could be identi®ed, appropriately taken preventive measures might improve perioperative cardiac outcome. Identi®ca...